Quimatryx Ltd has designed a best in class HDAC6 selective inhibitor, QTX125, with the aim of reducing the side-effects of the treatment and beating the therapeutic activity of other HDAC inhibitors.

In an in vivo xenograft assay with mantle cell lymphoma cell lines, QTX125 showed a spectacular tumour regression effect without toxicity. In addition, QTX125 does not present genotoxicity in rats and has successfully completed the in vitro hERG cardiotoxicity study.

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QTX125 compound and its clinical indications are fully protected by the corresponding patents: WO2011/039353, US8685992, EP2483242, ZL201080052814, MX314175, JP5746185, RU2549885



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