News and Publications

NEWS

EVENTS

PUBLICATIONS

  • Pérez-Salvia M, Aldaba E, Vara Y. et al. In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma. Haematologica. 2018, 103(11):e537-e540. DOI: 10.3324/haematol.2018.189241
  • Delgado-Camón A. et al. Resonance Driven Regioselective Demethylation of Berberine. Microwave Assisted Synthesis of Berberrubine and Its Assessment as Fluorescent Chemosensor for Alkanes. Tetrahedron Sept. 2015, 6148–6154. DOI: 10.1016/j.tet.2015.06.098
  • Otaegui, D. et al. Development and Validation of a LC-MS assay for the Quantification of IKH12 a novel anti-tumor condidate in rat plasma and tissues and its Application in a Pharmacokinetic Study. Biomedical Chromatography 2014. DOI: 10.1002/bmc.3414
  • San Sebastián E. et al. Design, Synthesis and Functional Evaluation of Leukocyte- Function Associated Antigen-1 (LFA-1) Antagonists in Early and Late Stages of Cancer Development. Journal of Medicinal Chemistry 2013, vol 56, pp. 735-747. DOI: 10.1021/jm3016848
  • Aginagalde M, Gómez-Vallejo V, Vara Y. et al. Synthesis of 11C-labeled Kendine 91, a histone deacetylase inhibitor. Appl Radiat Isot. 2012, 70(10):2552-2557. DOI: 10.1016/j.apradiso.2012.05.016
  • Arias L. et al. Regioselective preparation of benzo[b]furans from phenols and α-bromoketones. Journal of organic chemistry. 2012, vol 77, pp 266-275. DOI: 10.1021/jo201841y
  • Gómez-Vallejo V. et al. Biodistribution and metabolism of 11C-labeled Kendine 91 in mice and rats. Applied Radiation and Isotopes 2012, vol 70, pp. 2545-2551. DOI: 10.1016/j.apradiso.2012.05.020
    • Pérez-Perarnau A. et al. Analysis of apoptosis regulatory genes altered by histone deacetylase inhibitors in chronic lymphocytic leukemia cells. Epigenetics. 2011, 6(10):1228–1235. DOI: 10.4161/epi.6.10.17200
  • Aginagalde M, Bello, T. et al. Formation of γ-Oxoacids and 1H-Pyrrol-2(5H)-ones from α,β-Unsaturated Ketones and Ethyl Nitroacetate. Journal of Organic Chemistry. 2010, vol 75, pp 7435-7438. DOI: 10.1021/jo101388x
  • Zubia, A. et al. Identification of (1H)-pyrroles as histone deacetylase inhibitors with antitumoral activity. Oncogene 2009, vol 28(11), pp. 1477-1484. DOI: 10.1038/onc.2008.501
  • Otaegui, D. et al.Pharmacokinetics and tissue distribution of Kendine 91, a novel histone deacetylase inhibitor, in mice. Cancer Chemotherapy and Pharmacology, 2009, vol 64(1), pp 153-159. DOI: 10.1007/s00280-008-0857-9
  • Vara Y, Aldaba E. et al. Regiochemistry of the microwave-assisted reaction between aromatic amines and a-bromoketones to yield substituted 1H-indoles. Organic and Biomolecular Chemistry. 2008, vol 6(10), pp. 1763-1772. DOI: 10.1039/b719641e
  • Otaegui, D. et al. Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of Kendine 91, a novel histone deacetylase inhibitor, in mice plasma and tissue. Journal of Chromatography B. 2008, vol 870, pp.109-16. DOI: 10.1016/j.jchromb.2008.06.013
  • Zubia A. et al. Application of Stereocontrolled Stepwise [3+2] Cycloadditions to the Preparation of Inhibitors of alpha 4 beta 1-Integrin-Mediated Hepatic Melanoma Metastasis. Angewandte Chemie International Edition. 2005, vol 44, pp.2903-2907. DOI: 10.1002/anie.200462497
  • Erkizia E. et al. Stereocontrolled Formation of Substituted Imidazolidines in the Reaction Between N-metalated Azomethine Ylides and Isocyanates. ARKIVOC. 2005, (ix), pp 189-199. DOI: 10.3998/ark.5550190.0006.919 
  •